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Insufficient sun exposure, dietary inadequacies, and sedentary behaviors contribute to poor bone health and increased susceptibility to periodontal diseases

The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes

The average mortality rate is 4% to 10% from multiorgan failure (most commonly hepatic necrosis), 22 with long-term complications that include exfoliative dermatitis, 23 acute necrotizing eosinophilic myocarditis, and autoimmune sequelae such as thyroid disease, vitiligo, alopecia areata, lupus erythematosus, autoimmune hemolytic anemia, and fulminant type 1 diabetes mellitus

Take a 2007 observational study that found statin use lowered the risk for lung cancer, and two meta-analyses of RCTs that found statin use had no effect on cancer incidence