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This regulatory effect is partly mediated via the AMPK/sirtuin-1 (SIRT1) axis, as knockdown of SIRT1 abrogated the lipid-lowering and autophagy-inducing effects of GLP-1RAs, highlighting a crucial role of this pathway in regulating lipid metabolism by facilitating degradation of lipid droplets, thus preventing excessive lipid accumulation (12)

Burping and excess gas are among the most common early side effects reported in semaglutide clinical trials, typically peaking in the first 24 weeks as your body adjusts to the medication's effects