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In an animal study using 5-dihydrotestosterone + insulin treatment to simulate a miscarriage model in PCOS patients, NAC supplementation improved fetal survival rates in model mice by protecting mitochondrial function, restoring the balance of SOD1 and the Keap1/Nrf2 antioxidant response, reducing excessive ROS production, and mitigating placental formation defects [57]

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NERNST is a recently published sensor for measuring the NADP redox state 18

Consistent with the in vivo experimental results, these observations implied that Acsl4 knockout alleviated CaOX-induced mitochondrial dysfunction and reduced lipid peroxidation, thereby decreasing ferroptosis in MTECs