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A disruption of GSH homeostasis could induce oxidative stress and lead to neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinsons disease, Alzheimers disease, and dementia, with impaired motor and cognitive functions [7]

Following this initial patient characterization, mutations in the GATM gene and the SLC6A8 gene were found in patients exhibiting similar pathology to that seen with mutations in the GAMT gene

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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations