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Type 2 diabetes mellitus, characterized by insulin resistance and impaired insulin secretion, has become a major public health concern due to lifestyle changes, urbanization, and aging populations

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264,269 Furthermore, GLP-1 can slow down gastric emptying by activating the vagus nerve, a part of the autonomic nervous system crucial for regulating the activities of the gastrointestinal tract

The mechanism is not that semaglutide alters estrogen or progestin metabolism at the cytochrome P450 level