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In the large randomized cardiovascular outcome trials, an increase in urinary tract infections were not observed (143,144,156)
The condition is usually harmless, although it can cause psychological and social distress among those who have it
This is particularly relevant given the role of the brain stem in regulating the vagal pathway and the cholinergic antiinflammatory reflex (14), suggesting a possible yet under-investigated neuroimmune link
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