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The use of any mono-therapeutic drug in MDA as a disease control method provokes concern regarding its potential to induce drug resistance selection, particularly if the parent compound or its metabolites have a long elimination tail (Smits 2014)

doi:10.1016/j.psychres.2011.09.002, PMID: 22374552 Lynch T, Price A (2007) The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects

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1,7,8 and their potential responsiveness to modulation by prefrontal GABA