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Anyone considering this supplement should factor both of those realities into their decision: promising preclinical signal, very limited human clinical confirmation, no significant adverse effects observed in the small human studies that do exist

De Souza RL, Matsuura M, Eckstein F, Rawlinson SC, Lanyon LE, Pitsillides AA

Problems due to lack of cell division in fast dividing tissues: Anaemia, or any cytopaenia (including leucocytes, lymphocytes, platelets) Mouth ulcers, malabsorption, diarrhoea due to macrocytosis and atrophy of the intestinal mucosa as demonstrated by Foroozan and Trier

I built up to just walking round the block once a day