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The peptide has been characterized in tendon, ligament, muscle, gut, vascular, neural and bone injury models, where it consistently accelerates structural recovery, restores barrier function and rescues vascular perfusion through a coordinated upregulation of growth factor receptors, the nitric oxide system and angiogenic signaling [13]

On top of that, ERK1 and ERK2 proteins were also decreased in a concentration-dependent manner with curcumin (Malik et al., 2009)