tirzepatide elevated heart rate Zepbound Tirzepatide and elevated resting heart

Abd El Aziz MS, Kahle M, Meier JJ, Nauck MA (2017) A meta-analysis comparing clinical effects of short- or long-acting GLP-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients

Consequently, prospective randomized controlled trials (RCTs) are imperative to establish definitive causality

These risks and uncertainties include, but are not limited to, those factors described in the Risk Factors section of each of our most recently filed Quarterly Report on Form 10-Q, our most recently filed Annual Report on Form 10-K, and any of our subsequent filings with the Securities and Exchange Commission (the Commission)

However, the predominance of rodent studies raises questions about translatability to human pathophysiology and therapeutic responses