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Conclusion: This study identified five anti-fibrotic miRNAs enriched in MSC-EVs and revealed a mechanism for the suppression of fibrosis via down-regulation of RhoA signaling by MSC-EVs

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Human Evidence 1

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During a drug holiday specifically, sleep quality becomes even more important because you have lost the medication-driven appetite suppression that previously compensated for suboptimal sleep habits

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1.4% of placebo, highlighting tolerability challenges that may require optimization of dosing strategies or formulations [23]

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