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It is also instrumental in helping to detoxify or cleanse the liver of the toxins that the liver normally removes from the circulating blood
Interestingly, hyperoxia enhances GPx-1 transcription in human umbilical-vein endothelial cells through a mechanism independent of the ORE (190), suggesting that GPx-1 transcription may be regulated in response to oxygen tension by more than one mechanism
Additionally, OGD treatment resulted in a significant increase in FOXO4 expression (Figure 3C), and the accumulation of FOXO4 in the nucleus was more evident through immunofluorescence technology
