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Authors suggested that the changes observed was due to the degradation and cleavage of glycoside bonds leading to macromolecule de-polymerization and oxidation of functional groups to maintain carboxyl, carbonyl compounds, hydroperoxides, lactones, and CO 2 (Pankaj et al
Hence PDI proteins play a critical role in regulating the intracellular redox state, redox signaling, and in preventing protein misfolding and/or aggregation (Wang et al., 2015)
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