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If adequate glycemic control is not achieved after another 4 weeks, the dose can be increased to 1 mg once weekly

However, traditional metabolic profiling approachessuch as tissue homogenization coupled with gas chromatography- mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS)despite their success in identifying tumor-specific metabolic signatures, discovering prognostic biomarkers, and revealing adaptive metabolic responses under therapeutic stress limited (94)