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A marked depletion of beneficial taxa was identified, including a significant reduction in Ligilactobacillusa probiotic genus important for mucosal immunityas well as a pronounced decrease in Butyrivibrio, a key butyrate producer essential for gut barrier integrity, and a substantial decline in [Eubacterium]_siraeum_group, which is involved in SCFA production

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Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal treg cells and thereby attenuate arthritis

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