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It is likely that the center of the causal association between hyperuricemia and kidney disease progression should not be on patients with asymptomatic hyperuricemia, but rather on the population with gout.51 Key concepts none- Hyperuricemia increases the risk of developing hypertension, cardiovascular disease, and chronic kidney disease in the general population

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The study by Cacciari and colleagues showed that the factors regulating GH secretion during sleep may differ from those that influence GH secretion during wakefulness ( It was encouraging to see data showing some sleep improvements when children with GHD are treated with GH replacement therapy (30)