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Intelligent Pharmacy 2(6):768776

It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

Dosing for research peptides is typically calculated based on the weight of the test subject, often expressed in micrograms per kilogram (mcg/kg)

With the 10mg/ml concentration, a 1.25mg dose equals 12.5 units