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Healthcare providers should maintain awareness that while tirzepatide does not carry a formal GERD warning, gastrointestinal effects are common with this medication class, and reflux symptoms may emerge or change during treatment

Common Side Effects The most commonly reported adverse events are gastrointestinal in nature: Nausea (approximately 20-44% of participants) Diarrhea (approximately 30%) Vomiting (approximately 24%) These symptoms are typically mild to moderate in severity, tend to occur most frequently during dose escalation, and generally diminish over time as tolerance develops

Monitoring blood sugar levels, staying hydrated, and being cautious about the amount and type of alcohol consumed are critical steps in managing these risks

Disclosure of interest: Shakar Kutal: nothing to disclose