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Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes

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Ligands, receptors, enzymes, and signaling intermediates are preserved when their structural relationships continue to permit reliable and energetically feasible function

During a binge episode, the person feels unable to stop themselves eating, and it is often linked with high levels of distress