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2024, Shahid et al

CYP3A Inhibitors: Co-administration of a 180 mg daily dose of diltiazem with 5 mg amlodipine in elderly hypertensive patients resulted in a 60% increase in amlodipine systemic exposure

Unlike the cardiac samples, we observed several HFpEF-specific clusters in our UMAP, including a cluster of periportal-like hepatocytes (highlighted in Figure S7A-B ) and the cluster of proliferating cells that was significantly enriched in HFpEF in our cell type composition analysis ( Figure S7A, B )