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This model entails that, upon androgen binding, AR is activated, loses interactions with chaperone proteins, translocates to the nucleus where it binds as a dimer to AREs and activates or represses transcription of its target genes with the assistance of a large interactome of regulatory proteins (Fig

They are reference points for researchers designing their own evidence-based protocols

The resulting FRP review processes have clearly defined milestones and timelines for both the regulator and the applicant, with a preliminary assessment stage which allows filtering of applications which do not meet the requirements and prevents time wastage