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Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)

34 Cellular studies have suggested that ALA may induce nuclear localization of nuclear factor erythroid 2-related factor 2 (NRF2), the most important transcription factor regulating genes that contain the antioxidant response element, thereby modulating peroxisome proliferator-activated receptors-regulated genes

Mar 25 2020;21(7)doi:10.3390/ijms21072270