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One other downside that I think you didn't point to specifically, but you meant in saying there's some unknown downside to this, there are some early studies that are showing that you lose more lean muscle mass when you're on a GLP-1 than if you were just doing diet and exercise

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In addition to their role in hypertension, NPR1 agonists have gained attention in HF treatment because of their potential to improve hemodynamics and clinical symptoms

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