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In chronic fatigue syndrome, depression and GAD, the neurotoxicity theories conceptualize that the effects of neuro-oxidative stress toxicity (OSTOX) coupled with lowered antioxidant (ANTIOX) defenses cause increased neurotoxicity leading to somatic and affective symptoms [30, 31]

STEP 2 showed 1.0 mg kept about 73% of the 2.4 mg weight effect in type 2 diabetes with obesity. That is the clearest lower-dose weight evidence semaglutide has, though it is not the same as saying 1.0 mg equals 2.4 mg for everyone

Across major trials, GLP-1 receptor agonists have produced sustained weight loss, sustained improvements in glycemic control, and reductions in major cardiovascular events in patients with metabolic risk

These outcomes exceed those observed with both single and dual incretin agonists, highlighting the potential metabolic advantages of triple receptor agonism