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ADM tirzepatide prescribing rates increased +16.65% over the quarter, now at 1.18% Anti-obesity medication (AOM) prescribing increased in March 2025 compared to December 2024 (+17.01%)

This finding highlights that the same dietary and lifestyle interventions that promote natural GLP-1 release, discussed more below, can also help correct the underlying issues that impair GLP-1 in the first place (Huber et al, 2024)

This has several practical implications: Reflux and heartburn: Alcohol combined with delayed emptying increases stomach pressure and acid reflux Unpredictable intoxication timing: Alcohol absorption is erratic when gastric emptying is this delayed Increased vomiting risk: A stomach that remains full longer has a lower threshold for triggering vomiting Morning-after issues: That heavy stomach feeling can persist into the next day Practical Strategies for GI Management If you choose to drink while on retatrutide, GI management becomes critical: Eat substantial food 2-3 hours before drinking: Not immediately before, as that adds to gastric load Avoid carbonated alcoholic beverages: Carbonation increases stomach pressure and reflux risk Stay very hydrated: Water helps dilute stomach contents and reduces irritation Avoid high-acid drinks: Wine, especially white wine, and citrus-based cocktails increase gastric irritation Have antacids available: Calcium carbonate or famotidine can address acid-related discomfort Why Your Tolerance Just Tanked People who previously handled 3-4 drinks comfortably find themselves significantly intoxicated from 1-2 drinks on retatrutide

A sizable minority experience side effects like nausea