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PDB codes of previously published structures used in this study are 4HJE (human p53 DBD), 3L2C (human FOXO4 FH domain bound to DNA) and 1E17 (human FOXO4 FH domain)

Prescribing GLP-1s: Evidence, limits, expectations How physicians integrate GLP1s into long-term weight management GLP-1 medications are reshaping the conversation around metabolic health and weight loss but questions remain

Ozempic and Mounjaro are FDA-approved for the management of type 2 diabetes (with Ozempic also approved to reduce cardiovascular risk in T2D patients), but both are sometimes prescribed off-label at a providers discretion

Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity