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These heterogeneous responses are modulated by multiple factors, including tumor classification, study methodology, treatment duration, and patient-specific parameters (Table 1)

and M.B.: Conceptualization, Methodology, Data curation, Formal analysis, Writing original draft, Writing review & editing

Available from: J L Sievenpiper 1 2 3 , J Ard 4 , M Blher 5 , W Chen 6 , J B Dixon 7 , A Fitch 8 , L Gigliotti 9 , K Khunti 10 , A Lecube 11 12 , M E J Lean 13 , B Mittendorfer 14 , A F H Pfeiffer 15 , D H Ryan 16 , T Vilsbll 17 18 , L F Van Gaal 19

The G protein-coupled receptor of GLP-1 (GLP-1R) originally identified in islet -cells is widely expressed in extrapancreatic tissues as well including the lungs, kidney, brain, the enteric and peripheral nervous system, lymphocytes, smooth muscle cells (SMCs), and atrial cardiomyocytes [32] The specific identity of GLP-1 receptor-positive (GLP-1R+) cells in the heart remains uncertain