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Following 12 months of treatment, glucose management greatly improved than with Metformin alone, resulting in weight loss, improvement in blood glucose levels, increase in total and free testosterone levels and improvement in erectile dysfunction
Such patterns point to the potential of regional KP activity as a functional biomarker for stress-related symptom dimensions in MDD and highlight localized KP enzymes such as IDO, TDO, and kynureninase as candidate treatment targets
Cardiovascular Disease: Insulin resistance is strongly associated with an increased risk of cardiovascular disease
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