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For the once-weekly subcutaneous formulation, the SUSTAIN program (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) included 13 separate randomized clinical phase 3a and 3b trials (1013, 22, 2532) SUSTAIN 1 through 10 were global international trials, while three additional trials were specific for China and Japan

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This means contraception becomes essential if pregnancy is not desired, as ovulation may resume unexpectedly

doi: 10.4093/dmj.2016.40.5.354 [DOI] [PMC free article] [PubMed] [Google Scholar] 126