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Adverse Reactions in Pediatric Patients with HeFH In a 24-week, randomized, placebo-controlled, double-blind trial of 157 pediatric patients with HeFH, 104 patients received 420 mg REPATHA subcutaneously once monthly [see Clinical Studies (14)]

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It has also been shown that fibroblasts derived from patients with COPD were responsible for impaired collagen remodeling leading to MMP/TIMP imbalances