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Less frequent dosing the normal dosing regimen is once per week but patients who feel the appetite suppression effects of the medication last for 10 days or even 2 weeks can take the same amount less frequently

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A minimum of 2 sessions per week of bodyweight or weighted resistance exercise is recommended

Am J Med 105:54S-58S Tomassini V, Pozzilli C, Onesti E, Pasqualetti P, Marinelli F, Pisani A, Fieschi C (2004) Comparison of the effects of acetyl l-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial