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We think of this as a form of metabolic whiplash, and our data suggest it is detrimental to heart health." Serwer added that while GLP-1s are designed to enhance metabolic health, they should be combined with healthy behaviors to help ensure long-term benefits
Tirzepatide activates GLP-1 and GIP receptors, which signal your stomach to empty food more slowly and your brain to feel fuller faster
doi:10.1074/jbc.273.19.11660
Their conclusion is worth quoting in spirit: the preclinical results are promising and remarkably consistent, but high-quality randomized human trials are still lacking, and the compound sits in a real regulatory gray zone
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