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Pathogenic mutations in UPS components as direct drivers of neurodegeneration The indispensable role of the UPS in neuronal health is most clearly illustrated by familial forms of NDDs caused directly by mutations in UPS constituents

Bottom left : Elevated cytosolic Ca drives sustained muscle contraction and marked metabolic activation, increasing oxygen consumption, ATP utilization, and carbon dioxide production, thereby producing a hypermetabolic state

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Speaking at the ACR conference, she explained, The risk of cardiovascular disease is thought to be at least double in people with lupus