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The repository name and accession numbers are as follows: Gene Expression Omnibus (GEO), GSE53890

16. Byrne, K.L., Szeligowski, R.V., and Shen, H

When talking about needle sizes, "gauge" and "length" are the two critical factors to consider

When mast cells are activated in response to progesterone, the resulting histamine surge helps explain many of the hallmark features of APD, including: Hives (urticaria) caused by histamine-induced blood vessel dilation Intense itching (pruritus) driven by histamine signaling in the skin Angioedema , or deeper swelling beneath the skin and mucous membranes Asthma-like symptoms or shortness of breath , due to histamines effects on airway smooth muscle This mast cellhistamine connection also clarifies why treatments that target allergic pathways are often effective in APD, even though progesterone is a hormone rather than a classic allergen