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The impact on the IGF-1 axis is more complex: while IGF-1 levels may increase, this is often accompanied by higher IGF-binding proteins, which can mitigate tumor-promoting effects (32)

The thyroid gland was smooth and firm, and of normal size

For those with hyperthyroidism, the goal is often to reduce inflammation and avoid excess iodine, which can fuel hormone overproduction

Several mechanisms have been reported that explain the regulation of the concentration and activity levels of Keap1, such as transcriptional regulation (STAT6 and hypoxia-inducible factor) (59), miRNAs (miR-7 and miR-24-3p) (54), post-translational regulation, such as ubiquitination (60) and S-nitrosylation (61), as well as degradation of the Keap1 protein (p62-dependent autophagy) (62)