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Medical monitoring and supplementation: Regular blood tests to assess electrolyte levels and renal function are advisable, particularly for: Patients over 65 years Those with pre-existing kidney disease Individuals taking medications affecting electrolyte balance (diuretics, ACE inhibitors, NSAIDs) Anyone experiencing persistent gastrointestinal side effects Electrolyte supplementation should only be undertaken under medical supervision, as excessive supplementation can be harmful

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At the highest dose tested in Phase 2, retatrutide produced mean weight loss of 22.8% over 48 weeks a figure that sits above every previously reported trial of an approved GLP-1-class agent

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