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Nausea Often begins within 2472 hours after injection Typically improves within a few days to 2 weeks May reappear briefly after increasing the dose Zepbound and diarrhea If youre dealing with Zepbound and diarrhea, it usually: Starts in the first 12 weeks Improves within 37 days for many people May last up to a few weeks in some cases, especially after dose changes Does Zepbound cause constipation