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20 , 21 , 22 Given the encouraging results seen with semaglutide and other GLP1RAs in preclinical and human studies, two phase 3, randomized, placebocontrolled trials (evoke and evoke+) are investigating the safety and efficacy of oral semaglutide 14 mg in people with early AD (defined as biomarkerconfirmed, mild cognitive impairment due to AD or mild AD dementia) aged 55 to 85 years

They note that depression, a widely recognized mental health condition, often features anhedonia as one of its defining characteristics

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Healthy weight loss should ideally preserve lean tissue while reducing fat