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Common side effects include Nausea (most common, especially during dose increases) Vomiting Diarrhoea Constipation Abdominal pain Fatigue Most side effects are mild to moderate and improve over time

The following information is provided for context only and reflects the inclusion criteria used in the 2023 Phase 2 clinical trial (Jastreboff et al., NEJM 2023) these are study-specific criteria and do not represent current UK prescribing standards or predict future NICE commissioning decisions

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