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After exposure to an allergen, many inflammatory substances such as prostaglandins and cytokines are released, which leads to unpleasant symptoms

However, these adverse effects have been described as mild, with PubMed researchers concluding that berberine is a safe medicinal plant. Furthermore, no serious side effects were reported from berberine use in a study involving 2,569 patients (33)

Occasional headache or lightheadedness during initial use

Uncovering a GLP-1 receptor-independent pathway The researchers set out to understand the relationship between GLP-1 therapies and depression, specifically whether they affect the gut microbiome to modulate mood