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Diabetes mellitus, which is a complication of obesity, can activate satellite glial cells of the supracervical ganglia through P2Y receptors, resulting in increased expression of pro-inflammatory cytokines such as IL-1, and causing oxidative damage to the autonomic nerves such as via an inflammatory response (111, 112) ( Figure 2 )

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Additionally, GIPRs unique activation in the brain and white adipose tissue (WAT) might complement GLP-1R signaling, potentially improving therapeutic outcomes Figure 2

El CLA (cido Linoleico Conjugado) acelera la tasa metablica del cuerpo, promoviendo la prdida de peso y el mantenimiento de la masa muscular al mismo tiempo