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In horses with confirmed liver disease, the most common symptoms are: [9] Depression/lethargy present in 68% of cases Anorexia present in 56% of cases Weight loss present in 50% of cases Colic present in 50% of cases Diarrhea present in 42% of cases Jaundice present in 42% of cases Light sensitivity present in 16% of cases Blood clotting disorders present in 10% of cases Horses that have chronic liver disease progressing towards outright liver failure are likely to exhibit signs of weight loss, sensitivity to light, and increased susceptibility to sunburns

10.1016/j.jep.2017.11.028 66 DanisA.KilincY

However, the combined use of metformin and simvastatin led to the accumulation of SREBP2 and SCAP in vesicles, preventing their entry into the cell nucleus

Rubenstein, J