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295 In addition, high expression of TLR4 can increase H 2 O 2 production in the colonic mucosa of UC mice, induce redox activity in the mucosa, exacerbate oxidative stress, and promote the disease progression of UC

10.1053/j.gastro.2007.03.054 2 CataldoL

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83 Autotaxin inhibits autophagy via the AMPK pathway, thereby disrupting the mucosal barrier and aggravating intestinal inflammation, and AMPK agonists can significantly ameliorate this process, preventing intestinal inflammation and maintaining the integrity of the mucosal barrier