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Plasma data were modeled by non-compartmental analysis using WinNonlin software, dihexa exhibited a long half-life (ti /2 ) of 12.68 days following r administration and similarly when delivered intraperitoneally (8.83+/- 2.41 days, Mean +/- SEM

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In unstimulated HUVECs, VWF was observed in the endothelial cytoplasm but not on the cells surfaces, whereas in stimulated vessels, long VWF fibers up to 2 mm in length covered the vessel surfaces, binding to platelets predominantly irreversibly