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Although the ultimate goal of SCIT and SLIT is to induce immune tolerance, the differences in their drug-assing pathways lead to different initial immune activation sites and follow-up mechanisms

We think this could lead to new interventions, such as reducing the glutathione overload through synthesis inhibitors or compounds that can dissipate it. The findings also have implications for potential therapies for lung cancers related to mutations in the KEAP1 gene

DN mouse kidneys show increased lipid peroxides, which disrupt membrane permeability and exacerbate renal injury (138)

Guinan J, Wang S, Hazbun TR et al (2019) Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans