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In tau transgenic mice we saw improvements in brain structure and function by reducing senescent cell burden by 30% with an intermittent treatment strategy (35), which is consistent with preclinical studies on other models of aging and/or disease (37, 45, 46, 101-103, 108-112)

Taking the citrate supplement with meals helps get the citrate in with the oxalates and allows it to bind to the oxalates for removal from the body

28 : 418427 Kadowaki H, Nishitoh H, Urano F, Sadamitsu C, Matsuzawa A, Takeda K, Masutani H, Yodoi J, Urano Y, Nagano T and Ichijo H (2005) Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

Oben JE, Ngondi JL, Blum K