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Experimental Protocol 3: AT 1 -R Involvement in Amphetamine-Induced Angioplasticity 7 days After Withdrawal From days 1 to 10, the animals received VEH/CAND (3 mg/kg) by gavage using a feeding needle and from days 6 to 10 after VEH/CAND administration they were injected with SAL/AMPH (2.5 mg/kg, i

Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field

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