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Additional structural modifications included (i) substitution with aminoisobutyric acid at position 2 to increase resistance to DPP-4-mediated cleavage and inactivation, (ii) the addition of a C-terminal extension with 9 amino acids from exendin-4 to enhance structural stability, and (iii) acylation with a C16:0 fatty acid or PEGylation with 40 kDA PEG to extend in vivo activity, thus enabling daily or weekly administration, respectively [69]

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Janelle (26:30): It's only a certain percentage of people that might have that struggle, but like you said, there's so many things that can contribute to it

Novo Nordisk hit back almost immediately, placing an ad in The New York Times and USA Today called "Check Before You Inject." A company spokesperson said, at the point, that the ad was a "direct response" to the Hims & Hers' Super Bowl commercial