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Notably, depletion of microglia using the CSF1R antagonist PLX5622 attenuated stress-related transcriptional changes not only in microglia but also in leukocytes, endothelial cells, and astrocytes, underscoring the central role of microglia in orchestrating stress responses across multiple cell types

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Function of glycolysis in TME Recent studies have shown that lactate, as a metabolic molecule in the TME, maintains the survival of drug-resistant cells and supports epigenetic regulation through metabolism [242]

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