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3 The significance of ferroptosis in autoimmune diseases Originally identified as a mechanism to induce cell death in tumors, ferroptosis also plays a pivotal role in other conditions such as sepsis ( The functional states of immune and stromal cells are directly governed by their metabolic configurations, wherein microenvironmental cues reprogram core metabolism to dictate functional responses, while activation-induced functional shifts conversely demand adaptive metabolic remodeling ( In human hepatocellular carcinoma cell lines, both genetic or pharmacological disruption of DHCR7 and external administration of its metabolic substrate 7-dehydrocholesterol (7-DHC) effectively prevented the onset of ferroptosis ( 4 Ferroptosis and immune cells 4.1 T cells and B cells Ferroptosis, a type of iron-dependent cell death, involves distinct mechanisms in T cells and B cells ( Ferroptosis in CD8 + T cells is mediated by IFN- which is produced by activated CD8 + T cells and NK cells ( + T cells include TFH cells (Follicular Helper T cells) and Regulatory T Cells

We then used intersectional genetic targeting of PHOX2B + TRPV1 + neurons to more selectively target vagal Trpv1 -expressing cellsas confirmed by whole-animal imaging (Extended Data Fig

It is not metabolized by hepatic cytochrome P450 (CYP) enzymes

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